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Yet another medication developed specifically for migraines is a class of drugs called ditans, the Premium gnomes uff da christmas sweatshirt it is in the first place but first of which is a pill called Reyvow that was approved by the FDA last October. It works by activating serotonin receptors in the brain that block pain signals. Its website claims “you could be 100% pain free in two hours,” but it also warns against operating heavy machinery for at least eight hours after taking the drug, so if you happen to drive a car, it may not be right for you. Gottschalk and his colleagues at Yale are also researching psilocybin, the active ingredient in psychedelic mushrooms, which was just decriminalized in Oregon and has been indicated as a potential remedy for migraines, among many other ailments. “Our pilot studies are looking very promising,” he says. “You can take a sub-hallucinogenic dose of psilocybin, and stop cluster headaches for weeks, and migraines also.”

The Cefaly Dual, once a prescription-only device, which is the Premium gnomes uff da christmas sweatshirt it is in the first place but size of an eyeshadow compact and worn on the forehead, was just approved by the FDA as an over-the-counter treatment. It sends tiny electrical impulses to stimulate the trigeminal nerve, a cranial nerve that is a prime source of headache pain. Meanwhile, my sister, who has endured migraines for years, is one of the many fans of the ridiculous-looking but effective Magic Gel Headache and Migraine Relief Cap. Simply store the cap in the freezer to firm up its inch-thick layer of gel, then slip it on and wear until your migraine is manageable. Two other new FDA-cleared devices are controlled by smartphone: The Nerivio is a band worn on the upper arm, which sends electrical signals that disrupt pain pathways during a migraine episode, while an app called Juva Health provides clinician-developed biofeedback exercises, which studies show can reduce migraine severity by calming the nervous system.

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